Plaistow is a town in Rockingham County, New Hampshire, United States. The population was 7,609 at the 2010 census. The traditional pronunciation of the town name is plas-toh, but the pronunciation plas-tow is more common today.
Plaistow's economy is centered along New Hampshire Route 125, a north-south road that connects the town with Haverhill, Massachusetts to the south and Kingston, Epping, and Rochester to the north. Local businesses and numerous large chain stores are located along Route 125, which has become known for problems with heavy traffic during weekday commuting and weekend shopping hours.
Route 125 intersects with Interstate 495 in Massachusetts two miles south of Plaistow. Commuters to Massachusetts are able to use a New Hampshire park and ride facility located on Westville Road, just east of Route 125. Pan Am Railways (formerly the Boston and Maine Railroad) operates the main railroad line from Boston to Portland, which is utilized by Amtrak and by freight trains, running through Plaistow. Passenger stations for the Amtrak Downeaster are available in Haverhill to the south and Exeter to the north. A proposal has been made to extend existing MBTA commuter rail service from Boston through Haverhill, Massachusetts into Plaistow, and is being studied.